Endocrine Abstracts

Introduction: Treatment of hypothyroidism with levothyroxine is effective and simple; however, international guidelines advise starting with low doses in case of severe hypothyroidism, cardiac illness and aged population. Interestingly, and in contradiction to this dogma, high doses of levothyroxine have been given to patients with myxedema coma without untoward effects. The difference between myxedema coma, which deserves an intensive treatment, and longstanding severe hypoth...

Introduction: Papillary thyroid cancer (PTC) has an excellent prognosis in most cases with a 10-year survival rate of more than 95% but decreases drastically in cases of PTC iodine-refractory, in recurrent and/or metastatic disease. Tyrosine kinase inhibitors, such as lenvatinib or sorafenib, have been approved in such cases and in some cases are able to stabilize the disease and prolong survival. However, serious side effects have been reported such as fistula formation, blee...

Introduction: Many studies have shown that cigarette smoking exerts multiple effects on the thyroid gland. Smoking seems to induce changes in thyroid function tests, like a left-shift in serum TSH level that is more apparent in iodine-deficient subjects and increase in thyroid hormones. We describe the effect of an intensive thyroxine intravenous treatment in severe hypothyroid patients and the results depending on their smoking status.Material and metho...